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absorbed action activity administration amount animals apex appear arsenic arsphenamin auricular average basal metabolic blood body cause cent Chairman changes chlorid chloroform-soluble clinical compounds condition daily definite determined diabetes diet digitalis disease diuresis dosage dose drug edema effect evidence experience extract fact fever five fluid four give given heart hospital hypothyroidism important improvement increase indicate injection intake intravenous kidney laboratory lesion less March marked means ment mercury metabolic rate method months neo-arsphenamin nephritis nitrogen normal observations obtained occurred organism patient period possible preparation present probably produced protein pulse rate rats reaction reduced renal reports rest salt Secretary seems showed shown slight sodium solution spirochetes squill substance symptoms syphilis systolic Table technic tests therapeutic thyroid tincture tion toxic treated treatment wave weeks weight York
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Page 26 - This investigation has been made with the assistance of a grant from the Committee on Therapeutic Research, Council on Pharmacy and Chemistry. American Medical Association.
Page 210 - L'action du neosalvarsan et la reaction de Wassermann chez des malades attaints de tuberculides diverses, Ann. de dermal, et de syph. 44:470, 1913. Tzanck, A., and Pelbois, E. : A propos du traitement des tuberculoses cutanees et des tuberculides par le neosalvarsan, Ann. de dermat. et de syph. 45:65, 1914. Stokes, JH : Clinical Studies in Cutaneous Aspects of Tuberculosis. III. The Therapeutic Management of the Tuberculids, with Special Reference to the Efficiency of Arsphenamin, Am. JM Sc. 157:522,...
Page 163 - For practical therapeutic purposes the beneficial effects of arsphenamine are most apparent in a limited number of spirochetal diseases. They act as a specific in Vincent's angina, relapsing fever, yaws, gangosa, and pulmonary spirochetosis (if given early) in man and in equine influenza. A therapeutic effect is noted in rat-bite disease, in certain dental conditions, and in fowl spirochetosis. The complete measure of the effect in the latter condition has not yet been established. No apparent benefit...
Page 210 - Studies in the Treatment of Malaria. XVI. Intravenous Injections of Novarsenobillon in Simple Tertian Malaria, Ann. Trop. Med.
Page 213 - CONSERVATISM IN USE OF ARSPHENAMIN The last words of any discussion of the arsphenamins in therapeutics, should, I think, be an appeal for conservative interpretations. Particularly should such conservatism reign in the field of syphilis. Too short a time has elapsed since the discovery of these drugs, and too little is as yet known about the ultimate problems of the pathology, immunology and parasitology of syphilis, to justify the announcing of new infallibilities. The necropsy pathologist of the...
Page 192 - BIBLIOGRAPHY. Swift and Ellis: The Effect of Intraspinous Injections of Salvarsan and Neosalvarsan in Monkeys. Idem., p. 428. Swift and Ellis : The Treatment of Syphilitic Affections of the Central Nervous System with Special Reference to the Use of Intraspinous Injections. Arch. Int. Med., September, 1913, Vol. 12, p. 331. Myerson : Progress in the Treatment of Paresis by Salvarsanized Serum. Boston Med. and Surg. Jour., September 18, 1913. Robertson : General Paralysis of the Insane. Jour. Mental...
Page 174 - Investigation aided by funds accruing from the preparation of arsphenamin and neo-arsphenamin. 1. Kolmer, JA, and Lucke, B. : An Experimental Study of the Histopathological Changes Produced by Arsphenamin, Arch. Derm. & Syph. (in press) ; ibid. : An Experimental Study of the Histopathological Changes Produced by Neo-Arsphenamin, Arch. Derm. & Syph. (in press).
Page 206 - Sachs, B.: Truth About Intraspinal Injections in Treatment of Syphilis of Nervous System, JAMA 69:681 (Sept.
Page 163 - There is a limited effect on certain protozoal diseases, as malaria (tertian and quotidian), some of the trypanosomiases and leishmaniasis. It is possible, however, that this effect may be nonspecific. With the exception of anthrax, and possibly glanders, few favorable results are reported in bacterial diseases. Except in Vincent's angina, arsphenamin and neoarsphenamin should be administered intravenously in medium-sized dosage.
Page 102 - Biggins (HL) & Means (JH). The effect of certain drugs on the respiration and gaseous metabolism in normal human subjects. J. Pharmacol. & Exper. Therap., Baltimore, 1915-16, vii, 1-30.