Neural Degeneration and Repair: Gene Expression Profiling, Proteomics and Systems BiologyHans Werner Müller John Wiley & Sons, 2008 M03 31 - 249 pages With contributions from leading scientists around the world, this is the first book focussing on the analysis of nerve cell damage and repair using genomics, transcriptomics, proteomics and systems biology in order to develop novel therapeutic and diagnostic approaches for neural diseases. Following an introduction into the microarray technology in translational neuroscience, the book goes on to look at the use of '-omics' technologies to analyse molecular changes in traumatic injury, neuron degeneration and regeneration, oxidative stress response, neuropathic pain manifestation etc. The work covers central nervous system as well as peripheral nervous system pathologies. This novel approach makes the book an indispensable companion for neurobiologists, neurologists, cell and molecular biologists, geneticists, and analytical chemists. |
Contents
Microarrays in Systems Neurobiology and Translational | 1 |
Gene Expression Profiling Proteomics and Systems Biology | 35 |
WILEYVCH Verlag GmbH Co KGaA Weinheim | 61 |
Unraveling Plasticity of Dorsal Root Ganglion and Spinal Cord | 91 |
The Role of Gene Expression Dependent Molecular Pathways | 105 |
Axonal mRNA in Regeneration | 135 |
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Common terms and phrases
activity Affymetrix Alzheimer's disease array assays astrocytomas axon growth axon regeneration axotomy B-actin BDNF binding biological biomarkers Brain Research Butterfield Cancer cDNA cell body Cellular chips clinical cluster complex cytoskeletal dorsal horn dorsal root ganglion downregulated DRG neurons experimental functional gene expression changes gene expression profiling gene ontology genetic genome glioblastomas glioma growth cone high-throughput hybridization identified increase induced inhibitor Journal of Neuroscience kinase lesion levels metabolism methods mice microarray analysis molecular molecules motor neurons mouse mRNA nervous system neural neurite neurite outgrowth Neurobiology neurodegeneration Neurology neuropeptide novel oligonucleotide overexpression oxidative stress pathways patients peptide peripheral nerve injury phosphorylation probe set processes promote protein synthesis proteomics receptor regeneration-associated regenerative regulated genes response retrograde role samples sciatic nerve Sciences sensory neurons sequences specific spinal cord injury sprouting studies subunit synaptic target tissue transcription factors transection transport treatment tumor upregulated vimentin vitro vivo Zhang