Dopamine Receptor Subtypes: From Basic Science to Clinical ApplicationPeter Jenner, R. Demirdamar IOS Press, 1998 - 163 pages Multiple subtypes of dopamine receptors exist in the brain. This volume reviews the characteristics of D-1, D-2, D-3 and D-4 receptors and describes the current concepts of their involvement in motor disorders and in the control of schizophrenia. Readers: the book will be of great interest to professionals in pharmacology, medicinal chemistry, neuroscience, cell biology and therapeutic applications in clinical medicine as antipsychotics, anti-Parkinson's disease and related areas. |
Contents
Preface | 1 |
Biochemical Evidence for D Receptors not Linked to Adenylyl Cyclase | 8 |
Alterations in Dopamine Neurotransmission Produced by Genetic Knockouts | 29 |
Regulation of Psychomotor Behaviour | 45 |
Dihydrexidine and Parkinsons | 64 |
Efficacy of Dopamine D Receptor Agonists A86929 and ABT431 in Animal | 84 |
The Physiological Role of Dopamine D2 Receptors Y Bozzi and E Borrelli | 105 |
From Cloning to Function P Sokoloff N Griffon | 130 |
Dopamine D and D Receptors as Potential Therapeutic Targets K A Svensson | 148 |
Author Index | 163 |
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Common terms and phrases
adenylate adenylyl cyclase affinity agonists and antagonists antagonism antipsychotic autoreceptors basal behavioral binding c-fos cAMP analogs cell line clinical cloned cocaine compounds coupling cyclic AMP D-1 antagonists d-amphetamine D₁ D1 and D2 D₁A D₂ D2 Dopamine Receptor D3R KO mice D3R-mediated response dihydrexidine dopamine agonists Dopamine D2 Receptor dopamine neurons dopamine receptor dopamine receptor agonists dopaminergic doses drug dyskinesia effects efficacy forskolin full agonist functional G-protein gene grooming haloperidol increased induced inhibition inhibitory inositol phosphate interactions intrinsic activity involved isoforms Journal of Pharmacology kinase L-Dopa ligand locomotor activity mediated mg/kg mitogenesis mitogenic molecular monkeys mRNA mutant mice nafadotride Neuroscience neurotensin nucleus accumbens observed Parkinson's disease partial agonist Pharmacol Pharmacology PI hydrolysis potency primates protein Psychopharmacology quinpirole rat striatum receptor antagonist receptor subtypes role schizophrenia selective dopamine SK&F Sokoloff stimulation striatal slices striatum studies suggest synthesis therapeutic transfected ventral WT mice