Human Genetics: The Molecular RevolutionJones & Bartlett Learning, 1993 - 322 pages Begins with molecular characterization of the human genome (rather than the conventional descriptions of Mendelian inheritance, pedigree analysis, and chromosome abnormalities), and maintains this emphasis on understanding human genetics in molecular terms throughout. Suitable as a text for biology |
Contents
References | 7 |
Summary | 24 |
References | 34 |
Mapping by somatic cell genetics Mapping | 37 |
22335 | 50 |
DNA Sequencing | 58 |
4 | 64 |
Forward and Reverse Genetics | 93 |
Summary | 192 |
References | 201 |
Traditional Treatment Modalities | 213 |
Origin of Retroviral Oncogenes | 223 |
Tumor Suppressor Genes | 231 |
Functions of ProtoOncogenes | 237 |
The Role of Oncogenes in Tumor | 244 |
Genetics of the Immune | 256 |
28 | 99 |
33 | 113 |
RAPD A New Way to Find | 115 |
An explanation of the strategies used | 125 |
Summary | 136 |
PremRNA | 144 |
Chromosomal Mutations | 152 |
34 | 160 |
B cells and the antibody response Antibody | 268 |
244 | 278 |
248 | 284 |
Organization of mitochondrial DNA | 294 |
Mitochondrial Structure and Function | 309 |
Summary | 316 |
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Common terms and phrases
abnormal activity affected persons alpha-globin amino acid amplified antibodies antigen assay autosomal dominant beta-globin bind blood cause cDNA chain Chapter chromo clones coding codon contain copies crossing-over crossovers cystic fibrosis deletion denatured detected diagrammed disease locus DNA molecules DNA sequences Duchenne muscular dystrophy electrophoresis encoded example exon expression females Figure fragments frequency function gamete gene mapping gene therapy genetic diseases genotype globin haplotypes heterozygotes homozygotes homozygous HPRT human chromosome human genome hybrid cells identified inactivation inheritance introns kinase known linkage analysis lod score mammalian marker loci methylation mitochondrial molecular mRNA mutant allele mutation rate normal nucleotide occur oncogenes parents patients pedigree phenotype polymerase polymorphic polypeptide possible present primers probe produce protein receptor recessive allele recombination region restriction enzyme result RFLPs screening somatic cell Southern blotting specific splice syndrome tion tissues transcription translocation tumor X chromosome X-CGD X-linked zygote